General Information

  • ID:  hor002297
  • Uniprot ID:  A0A3P9JPF5(120-136)
  • Protein name:  Melanin-concentrating hormone
  • Gene name:  NA
  • Organism:  Oryzias latipes (Japanese rice fish) (Japanese killifish)
  • Family:  Melanin-concentrating hormone family
  • Source:  animal
  • Expression:  Brain
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Oryzias (genus), Oryziinae (subfamily), Adrianichthyidae (family), Adrianichthyoidei (suborder), Beloniformes (order), Atherinomorphae (superorder), Ovalentaria, Percomorphaceae, Euacanthomorphacea, Acanthomorphata, Ctenosquamata, Eurypterygia, Neoteleostei, Euteleosteomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0030354 melanin-concentrating hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway; GO:0007268 chemical synaptic transmission
  • GO CC:  GO:0045202 synapse

Sequence Information

  • Sequence:  DTMRCMVGRVYRPCWEV
  • Length:  17(120-136)
  • Propeptide:  MRRSVMSVIFATVLLFDCYAPSVASPMANTEDGSMEQDAFTSLLTNEATDNSLGEAEPIPVTKARVPRVIVIAADPSLWRDLRVLHGGMSVYRRTADDNNQVLEHRNLAQQLNIPILRRDTMRCMVGRVYRPCWEV
  • Signal peptide:  MRRSVMSVIFATVLLFDCYAPSVA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  May be involved in modulating medaka behaviors
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-A0A3P9JPF5-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor002297_AF2.pdbhor002297_ESM.pdb

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Physical Information

Mass: 238707 Formula: C89H141N27O24S4
Absent amino acids: AFHIKLNQS Common amino acids: RV
pI: 8.22 Basic residues: 3
Polar residues: 5 Hydrophobic residues: 4
Hydrophobicity: -23.53 Boman Index: -4035
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 51.18
Instability Index: 1675.88 Extinction Coefficient cystines: 7115
Absorbance 280nm: 444.69

Literature

  • PubMed ID:  19118555
  • Title:  Mass Spectrometric Map of Neuropeptide Expression and Analysis of the Gamma-Prepro-Tachykinin Gene Expression in the Medaka (Oryzias Latipes) Brain